# Efficacy of the Improving Participation after Stroke Self-Management-Rehabilitation (IPASS-R) program in sub-acute stroke

> **NIH NIH R01** · UNIVERSITY OF MISSOURI-COLUMBIA · 2024 · $622,901

## Abstract

Project Summary/Abstract
 The long-term goal of this research is to improve self-efficacy, activity performance, and health in
individuals with stroke. Current stroke rehabilitation research and practice must be addressed to shift the focus
of the field from an over-emphasis on impairment reduction to management of stroke as a chronic disease.
The overall hypothesis of this proposal is that a clinically feasible, self-management-based intervention, the
Improving Participation after Stroke Self-Management Rehabilitation (IPASS-R) program, will produce a
significant improvement on measures of self-efficacy, activity performance, quality of life, and community
engagement outcomes as compared to a general health-focused self-management program, the Chronic
Disease Self-Management Program (CDSMP). All assessment and intervention procedures will be conducted
virtually via videoconferencing. The specific aims of this project in the subacute stroke population are to: (1)
evaluate the efficacy of IPASS-R to improve self-efficacy within home, community, and work activity
performance; (2) evaluate the efficacy of IPASS-R to improve activity performance and quality of life; and (3)
explore the effect of IPASS-R on objective measures of in-home activity patterns and community engagement.
Participants with subacute stroke living in the community will be recruited through local hospitals at two sites (n
= 100). Those individuals who meet eligibility criteria will be randomized to either an IPASS-R group or to a
CDSMP group. Both groups will receive six, 90-minute group sessions of self-management education.
Treatment outcomes will be assessed at baseline, post-intervention, and at six-months post-intervention.
Treatment efficacy outcomes will be analyzed with an intent-to-treat model with an analysis of covariance
(ANCOVA). Potential covariates will include age, stroke severity, degree of cognitive impairment, and degree
of motor impairment. Independent samples t-test and chi-square test will be used to ensure successful
randomization and balance between groups. Group differences at baseline that are statistically significant will
also be considered as covariates in the analysis. Post-hoc tests will be employed as appropriate. Significance
levels, effect sizes, and confidence intervals will be reported. Completion of this study is likely to result in an
efficacious, clinically feasible intervention to improve self-efficacy, activity performance, and participation in
individuals with stroke that can be feasibly implemented into current systems of care. The proposed study and
anticipated outcomes are consistent with the research priorities of the National Center for Medical
Rehabilitation Research (NCMRR), which include which include rehabilitation interventions focused on chronic
symptom management with real-world, participatory outcomes and objective markers of functional progress.

## Key facts

- **NIH application ID:** 10856613
- **Project number:** 1R01HD114732-01
- **Recipient organization:** UNIVERSITY OF MISSOURI-COLUMBIA
- **Principal Investigator:** Anna Boone
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $622,901
- **Award type:** 1
- **Project period:** 2024-08-01 → 2029-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10856613

## Citation

> US National Institutes of Health, RePORTER application 10856613, Efficacy of the Improving Participation after Stroke Self-Management-Rehabilitation (IPASS-R) program in sub-acute stroke (1R01HD114732-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10856613. Licensed CC0.

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