# CORE 4 - Genetics, Single Cell Sequencing and RNA seq Core

> **NIH NIH P30** · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $164,000

## Abstract

Genetics, Single-Cell Sequencing, and RNASeq Core
PROJECT SUMMARY/ABSTRACT - Genetics, Single-Cell Sequencing, and RNASeq Core.
The Genetics, Singe-Cell Sequencing, and RNASeq Core will provide NORC investigators with access to, and
assistance with, state-of-the-art molecular methods based on Next Generation Sequencing. Our major goal is to
make the technology accessible to NORC investigators who may not have the resources or experience to take
full advantage of these methods. We will pursue two complementary approaches. First, we will generate a
graphical user interface to provide NORC investigators with access to a database of precomputed tests for
genetic association in the Dallas Heart Study, and the Dallas Biobank. NORC Investigators will query the
database by genotype (e.g. a gene symbol or genetic marker) to identify traits associated with that gene or
marker in the DHS), or by phenotype, to identify genes and mutations that contribute to that phenotype. Data
from whole exome sequencing and whole genome microarrays is available for participants in both of these
studies and phenotype data relevant to NORC investigators has been collected. This resource will enable NORC
investigators to exploit the unique advantages of human genetics to dissect cause-effect relationships in
metabolic pathways and to identify novel components of these pathways. Second, we will assist NORC
investigators with the design and interpretation of their NGS-related experiments. Laboratory analyses will be
performed by the McDermott Center Sequencing Core. We will focus on genetics, single-cell sequencing and
RNASeq because these methods are by far the most widely requested services by investigators at UT
Southwestern. Our Specific Objectives are: 1) Assist NORC Investigators to use genetic association and
Mendelian Randomization and whole genome/exome sequencing; 2) Enable NORC investigators to use Single-
cell sequencing and provide analysis of results; and 3) Assist NORC investigators with the design and
interpretation of RNASeq analyses in a reliable, cost-effective manner.

## Key facts

- **NIH application ID:** 10857183
- **Project number:** 5P30DK127984-03
- **Recipient organization:** UT SOUTHWESTERN MEDICAL CENTER
- **Principal Investigator:** JONATHAN Charles COHEN
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $164,000
- **Award type:** 5
- **Project period:** 2022-07-01 → 2027-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10857183

## Citation

> US National Institutes of Health, RePORTER application 10857183, CORE 4 - Genetics, Single Cell Sequencing and RNA seq Core (5P30DK127984-03). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10857183. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*