# Admin Core

> **NIH NIH U2C** · FRED HUTCHINSON CANCER CENTER · 2024 · $428,269

## Abstract

Project Summary/Abstract (Administrative Core Component, RFA-CA-22-040)
 We propose to develop a blood-based test whose indicated use is to complement mammography in the early
detection of breast cancers. Although mammography saves lives through early detection, it is imperfect.
Approximately one in seven breast cancers goes undetected despite screening mammography, and interval
cancers that manifest within a year of a normal mammogram remain a vexing problem, especially (although not
exclusively) for the >27 million women in the United States with heterogeneously or extremely dense breasts at
high risk for interval cancers. We propose to develop a blood test that could be used as an adjunct to
mammography to improve early detection by improving sensitivity and/or specificity of mammography.
 Using a novel biomarker discovery approach leveraging human-in-mouse breast cancer patient-derived
xenograft models and state-of-the-art mass spectrometry methods, we prioritized a subset of 162 candidate
breast cancer protein biomarkers (verified in human plasma from breast cancer cases vs. controls) for follow up
EDRN phase 2 validation studies in this proposed BCC.
 Our project will clinically validate and deploy (in our CLIA laboratories) a novel multiplex immuno-multiple
reaction monitoring mass spectrometry (immuno-MRM-MS) assay to perform EDRN phase 2 biomarker
validation studies using strongly unbiased sets of plasma samples obtained from existing biorepositories.
 The Administrative Core will support all aspects of the BCC, including managing all administrative and project
management aspects of the BCC (e.g., budgets, contracts, timelines, IRB documentation, site visits, travel
arrangements, progress reports, manuscript submission), as well as managing all center logistics and
communication (e.g., coordination of all communications within the BCC, between the BCC and NCI, and
between our BCC and others in the Network).

## Key facts

- **NIH application ID:** 10857307
- **Project number:** 5U2CCA271873-02
- **Recipient organization:** FRED HUTCHINSON CANCER CENTER
- **Principal Investigator:** AMANDA G PAULOVICH
- **Activity code:** U2C (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $428,269
- **Award type:** 5
- **Project period:** 2023-06-05 → 2028-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10857307

## Citation

> US National Institutes of Health, RePORTER application 10857307, Admin Core (5U2CCA271873-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10857307. Licensed CC0.

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