# Temporal effects of CD8 T-cells post-MI

> **NIH NIH R01** · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2024 · $517,431

## Abstract

Summary: For patients who have a heart attack (myocardial infarction; MI), 1 in 3 will not survive 5 years after
the event. Therefore, there is a critical need to facilitate the long-term goal of providing potential intervention
targets to prevent, slow, or reverse progression to heart failure in heart attack patients. The long-term goal of
the proposal is to understand how CD8+ T-cells are impairing the wound healing response after MI leading to
eventual development of heart failure. The specific objective is to understand the temporal changes in the
genetic and physiological profiles of the CD8+ T-cell population and how this regulates cardiac wound healing
after a heart attack. The central hypothesis is that temporal changes in CD8+ T-cell heterogeneity mediates
alterations of the constitutive properties of the ischemic scar and subsequent ventricular dysfunction. Aim 1 will
test the hypothesis that temporal regulation of CD8+ T-cell activation is a fundamental determinant of the
constitutive properties of ischemia induced myocardial scar. Aim 2 will test the hypothesize that CD8+ T-cell
downstream effects during post-MI remodeling are not fully regulated by antigen presentation. This proposal
will take a cutting-edge and integrative multidisciplinary approach to evaluate CD8+ T-cells in the MI setting.
The completion of the study will provide a better understanding of critical mechanisms underlying adverse
effects of the adaptive immune response and wound healing after MI. The proposed study aligns with the
mission of the healthcare system by providing molecular knowledge to clinical practices so that we can
continue to provide exceptional health care that improves patient health and well-being.

## Key facts

- **NIH application ID:** 10858009
- **Project number:** 1R01HL173273-01
- **Recipient organization:** MEDICAL UNIVERSITY OF SOUTH CAROLINA
- **Principal Investigator:** Kristine Y DeLeon-Pennell
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $517,431
- **Award type:** 1
- **Project period:** 2024-05-10 → 2029-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10858009

## Citation

> US National Institutes of Health, RePORTER application 10858009, Temporal effects of CD8 T-cells post-MI (1R01HL173273-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10858009. Licensed CC0.

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