# Core A Mouse Genetics and Genomics Core

> **NIH NIH P01** · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2024 · $425,317

## Abstract

Core A: Mouse Genetics and Genomics (Core Leader: Ferris)
Abstract
Mouse models of human diseases, such as Mycobacterium tuberculosis (Mtb), have proven invaluable for
understanding the underlying genetic, molecular and physiological or immunological basis of these disease
processes. Recent work has shown that mouse models that incorporate population-wide genetic diversity can
model unique aspects of the response to Mtb infection, as well as immunization against Mtb, with several of
these strains recapitulating unique aspects of human disease. The mouse genetics core serves this larger
program by identifying/confirming the genetic features driving these unique aspects of host responses to Mtb via
experimental crosses and infection or immunization studies between mouse strains segregating candidate
genome regions, concurrent with genomic and transcriptomic refinement of the candidate variants and pathways.
Lastly, the core will incorporate the results of these analyses to generate improved models of Mtb disease via
the generation of new congenic or mutant mouse strains for the research projects to dissect the impact of these
models and genetically variable pathways on Mtb disease.

## Key facts

- **NIH application ID:** 10861326
- **Project number:** 1P01AI181898-01
- **Recipient organization:** UNIV OF MASSACHUSETTS MED SCH WORCESTER
- **Principal Investigator:** CHRISTOPHER M SASSETTI
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $425,317
- **Award type:** 1
- **Project period:** 2024-08-20 → 2029-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10861326

## Citation

> US National Institutes of Health, RePORTER application 10861326, Core A Mouse Genetics and Genomics Core (1P01AI181898-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10861326. Licensed CC0.

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