All manual lifting and repositioning techniques have a high-risk for injury to caregivers. Work-related back pain and injuries are a widespread epidemic and due in large part to repeated patient handling activities, including lifting, transferring, and repositioning tasks. Bed to chair and chair to toilet transfers are consistently ranked among the most physically stressful tasks required of patients and caregivers. Mechanical transfer assist devices were found to reduce the risk of injury to caregivers. Consequently, several states have passed bills requiring all hospitals to establish a ‘no manual lift’ policy for staff members who interact directly with patients to reduce the risk of work-related musculoskeletal disorders. The most commonly used lift technologies for dependent transfers of patients include the overhead ceiling lift, the floor-based sling lift, and the Gantry lift. While these devices allow for safer transfer of patients, they do so with shortcomings. Overhead sling lifts require extensive installation that may not be suitable for homes or buildings with structural deficiencies or a low ceiling. Floor-based sling lifts have several issues with caregiver manipulation and ease of use. Gantry lifts are very difficult to move and store due to their size. Research has demonstrated that people with mobility impairments and caregivers both desire new, powered devices for safer and more comfortable and independent transfers. The AgileLife Patient Transfer and Movement System (PTS) developed and commercially deployed by Next Health, LLC is an integration of several assistive technologies that together automate the transfer of immobile individuals to and from a hospital bed and a wheelchair. The PTS includes a hospital bed, an integrated and detachable wheelchair/commode chair, a docking system, and a transfer ‘sheet’ that moves the individual to and from the bed. The existing PTS was not originally designed for power wheelchairs or independent use. However, a recent project developed modifications to a group 3 power wheelchair so that it would be compatible with the AgileLife bed. The goals of this project will be to iteratively redesign, prototype and test the modified PTS and a compatible group 3 power wheelchair so that the system could be be used by a greater number of people with physical disabilities and independently. This will be accomplished by conducting focus groups to determine the how the user interface should function for independent use; refining the design of the bed and the group 3 power wheelchair; completing usability testing of the new system; and conducting Clinical Limits of Use Testing to identify situations and user characteristics for appropriate and inappropriate use for the system.