# Microbiomics and Functional Genomics Core

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $235,584

## Abstract

Summary
 The overall objective of the Microbiomics and Functional Genomics Core is to facilitate digestive diseases
research by providing advanced microbiomics and functional genomics services to members of the San Diego
Digestive Diseases Research Center (SDDRC). Central to the Core services are next-generation sequencing
technologies, which have revolutionized basic and translational medical research over the last several years and
are in increasing demand in digestive diseases research. The Core enables Center investigators to conduct and
interpret studies based on large-scale sequencing by removing technical and cost barriers that can limit
successful application of these powerful tools. In addition, the Core provides a comprehensive set of services
beyond sequencing that empower Center members to use microbiomics and functional genomics technologies
without extensive preexisting expertise on their side for sample preparation and data analysis. The Core is
directed by internationally recognized experts in microbiomics (Dr. David Pride) and functional genomics (Dr.
Sven Heinz). Together with a team of experts in microbiome science, molecular genetics, bioinformatics and
computational biology, the Core leadership has a wealth of experience in guiding SDDRC members in the use
and analysis of cutting-edge and cost-effective technologies for microbiomics and functional genomics. The Core
has had excellent success in serving its membership as evidenced by usage by 70% of SDDRC members;
processing and sequencing of ~10,000 microbiome and ~4,000 genomic samples; over 6,000 hours of
bioinformatic analysis; and acknowledgement of Center support on 72 publications based upon primary usage
of services by this Core. Building on these achievements, the Core will continue to leverage three established
institutional shared resources for providing services: the Microbiome Core at the University of California, San
Diego (UCSD), the Genomics Center of the Institute for Genomic Medicine (IGM) at UCSD, and the UCSD
Center for Computational Biology and Bioinformatics. Service entails sample preparation, sequencing and data
analysis in an integrated workflow whereby samples are processed either at the Microbiome Core or IGM
Genomics Center, sequencing is performed at the IGM Genomics Center, and data are seamlessly transferred
and analyzed in the Center for Computational Biology and Bioinformatics. The Core also offers consultation and
training in genomics technologies to enhance the ability of members to implement these technologies in their
research. The Core has established rigorous procedures for quality control and data validation, and interacts
with and complements the other SDDRC Cores. Together, the unique combination and integration of outstanding
existing infrastructure and expertise enables the Core to provide a range of high quality and cost-effective
microbiomics and functional genomics services that greatly enhance the ability of Center members to adv...

## Key facts

- **NIH application ID:** 10861668
- **Project number:** 2P30DK120515-06
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** David Tevis Pride
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $235,584
- **Award type:** 2
- **Project period:** 2019-07-01 → 2029-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10861668

## Citation

> US National Institutes of Health, RePORTER application 10861668, Microbiomics and Functional Genomics Core (2P30DK120515-06). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10861668. Licensed CC0.

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