Project Summary (Administrative Core) The overall objective of the Administrative Core is to provide leadership, guidance and efficient operation and management of the Oklahoma COBRE in Structural Biology (OCSB). For this we have developed effective oversight, fiscal responsibility and transparent administrative policies. The PI/PD, Dr. West, will direct the Administrative Core and is responsible for all administrative, financial and reporting functions of the OCSB. She will be assisted by the Associate Program Director Dr. Gillian Air, the Scientific Program Coordinator Dr. Janiak-Spens, and a full-time administrative staff assistant who will help manage financial, scientific and communication aspects of the center. An outstanding team of advisors (Steering Committee, IAC, EAC) and mentors will monitor and guide the progress of the pilot project leaders and research core facilities. The Administrative Core is responsible for coordinating the activities of the OCSB, communication with the oversight committees, core directors and mentors, preparation of progress reports, management of the pilot project program, and organization of the external speaker seminar series. The specific aims of the Administrative Core are to: 1) Oversee programmatic and financial management of the center with input from stakeholders and advisory committees; 2) Ensure that the scientific cores remain productive and on a path towards a long-term sustainable future; 3) Administer an effective pilot project program from pre-award to post- award; and 4) Serve as a nexus for structural biology in the State of Oklahoma through targeted outreach and educational activities.