# Vanderbilt University Medical Center (VUMC) CoFAR Clinical Research Center

> **NIH NIH U01** · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $678,356

## Abstract

PROJECT SUMMARY/ABSTRACT
This application is in response to RFA-AI-22-076 to establish a Clinical Research Center at Vanderbilt University
Medical Center for the Consortium of Food Allergy Research. The goal of this application is to establish the
infrastructure for a CRC that will then successfully, efficiently, and rigorously conduct both CoFAR-wide clinical
studies along with advancing the science and understanding of the food allergy syndrome related to alpha-gal.
These goals will be pursued via the following specific aims:
Specific Aim 1: Establish infrastructure for the VUMC CoFAR CRC, which is capable of rapidly implementing
and executing single site and multi-center clinical trials, with high quality and fidelity, focused on the prevention
and management of patients with food allergy, supplemented by studies to better elucidate the mechanisms
underlying food allergies and, in particular, alpha-gal syndrome. This CRC will serve as an opportunity for New
and Early-Stage Investigators to contribute to these projects and advance their independent research careers.
Specific Aim 2: Develop and conduct a consortium-wide, multi-center, non-inferiority clinical trial to evaluate the
comparative effectiveness of early peanut introduction with once weekly peanut feeding (low weekly peanut
protein dose, 2 gm) versus thrice weekly peanut feedings (standard weekly peanut protein dose, 6 gm) in the
prevention of peanut allergy in at risk infants.
Specific Aim 3: Based upon the concept that alpha-gal syndrome (AGS) is clinically manifest as a wide spectrum
of clinical presentations, we aim to better understand (1) why some patients in tick-endemic areas develop
clinically evident AGS after a bite, while others do not, and (2) why the clinical expression of AGS is variable
amongst patients and changes over time.

## Key facts

- **NIH application ID:** 10862098
- **Project number:** 1U01AI181927-01
- **Recipient organization:** VANDERBILT UNIVERSITY MEDICAL CENTER
- **Principal Investigator:** Leonard B Bacharier
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $678,356
- **Award type:** 1
- **Project period:** 2024-03-14 → 2031-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10862098

## Citation

> US National Institutes of Health, RePORTER application 10862098, Vanderbilt University Medical Center (VUMC) CoFAR Clinical Research Center (1U01AI181927-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10862098. Licensed CC0.

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