# Center for Identification and Study of Individuals with Atypical Diabetes Mellitus

> **NIH NIH U54** · UNIVERSITY OF CHICAGO · 2024 · $2,500,000

## Abstract

OVERALL COMPONENT – PROJECT SUMMARY/ABSTRACT
The NIH-funded Rare and Atypical Diabetes Network (RADIANT) will continue to refine methods to diagnose
individuals with atypical diabetes, identify etiologic genomic variants, and establish the underlying
pathophysiology of disease in order to bring precision medicine to clinical practice. In so doing, RADIANT will
expand and manage a database and biospecimen repository for storage of data and samples from individuals
with rare/atypical forms of diabetes for future analyses.
RADIANT includes 14 clinical centers: Baylor College of Medicine (BCM), University of Chicago, University of
Washington, Seattle Children’s Hospital, University of Colorado, SUNY Downstate Health Sciences University,
Indiana University, Columbia University, Massachusetts General Hospital, University of Maryland, University of
Michigan, University of North Carolina, Vanderbilt University, and Washington University in St. Louis. The Data
Coordinating Center at the University of South Florida is responsible for the coordination and support of the
study protocol, data collection and analysis.
The RADIANT Central Laboratory at the University of Florida is responsible for all biochemical analyses,
autoantibody testing, DNA and RNA extraction. Whole-genome sequencing and interpretation is conducted at
the Broad Institute and RNA sequencing at BCM. Plasma metabolomic profiling is performed at Duke
University and monocytes are preserved for pluripotent stem cell derivation at BCM. The study is overseen by
the University of Utah Institutional Review Board.
The genotypic and phenotypic analyses should enhance the identification of cases with atypical diabetes.
Whole-genome sequencing could help identify new genetic variants and metabolomics and transcriptomics
analysis novel pathogenic mechanisms and biomarkers for atypical forms of the disease. Its ultimate goal is to
enable a more precise, etiologically based clinical classification of diabetes.

## Key facts

- **NIH application ID:** 10862191
- **Project number:** 2U54DK118612-06
- **Recipient organization:** UNIVERSITY OF CHICAGO
- **Principal Investigator:** Louis H. Philipson
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $2,500,000
- **Award type:** 2
- **Project period:** 2018-09-10 → 2029-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10862191

## Citation

> US National Institutes of Health, RePORTER application 10862191, Center for Identification and Study of Individuals with Atypical Diabetes Mellitus (2U54DK118612-06). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10862191. Licensed CC0.

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