# Discovery and Analysis Project

> **NIH NIH U54** · UNIVERSITY OF CHICAGO · 2024 · $1,953,208

## Abstract

Discovery and Analysis Project
Project Summary
Diabetes is traditionally classified in two broad categories: autoimmune Type 1 and obesity-related Type
2. Numerous phenotypically and etiologically distinct forms exist and are emerging, collectively termed
“atypical diabetes”, that do not fit into either category. We hypothesize that atypical diabetes comprises a
spectrum that includes numerous forms, both known (e.g., MODY/monogenic, Ketosis-Prone Diabetes)
and unknown. During the current U54 funding cycle we established the Rare and Atypical Diabetes
Network (RADIANT), with a well-functioning infrastructure to identify and enroll participants with atypical
diabetes; a pipeline for harmonized screening and adjudication of enrolled participants; full genomic
characterization of participants via whole genome sequencing; transcriptomic characterization via RNA
sequencing; quantitative plasma metabolomics; patient-specific, inducible pluripotent stem cell-based
molecular physiology; enrollment of informative family members; and both standard and specialized
phenotyping for each participant. In the next cycle of RADIANT, we propose to continue to recruit persons
with atypical forms of diabetes to fulfill the original goals, together with discovery and analysis of the
mechanisms and pathways that define these new forms of diabetes, by achieving the following Aims: 1)
Continue the identification, genome sequencing, transcriptomic and metabolomic interrogation, and deep
phenotyping of individuals and families with atypical forms of diabetes; 2) Discover and describe new forms
of monogenic diabetes; 3) Expand and enrich the growing database to characterize atypical diabetes and
recognize different genotypic and phenotypic clusters; and 4) Determine the pathophysiological
mechanisms of atypical diabetes genomic variants. Thus, in the next cycle of RADIANT, our collaborative,
multidisciplinary and diverse group of accomplished diabetes investigators will expand our repository of
atypical diabetes cases, identify new disease mechanisms, target pathogenic pathways, advance our
understanding of diabetes pathophysiology and develop an improved, etiologically based classification of
diabetes.

## Key facts

- **NIH application ID:** 10862194
- **Project number:** 2U54DK118612-06
- **Recipient organization:** UNIVERSITY OF CHICAGO
- **Principal Investigator:** Louis H. Philipson
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,953,208
- **Award type:** 2
- **Project period:** 2018-09-10 → 2029-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10862194

## Citation

> US National Institutes of Health, RePORTER application 10862194, Discovery and Analysis Project (2U54DK118612-06). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10862194. Licensed CC0.

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