# Clinical Core

> **NIH NIH U19** · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · 2024 · $290,923

## Abstract

Clinical Core
Principal Investigator: Asuncion Mejias, M.D.
Abstract
This Core will serve three main goals. First, by enrolling all patients, obtaining the human samples, and collecting
the clinical data it will simplify sample organization, data management and compliance with all regulatory aspects
of the U19. In addition, the Clinical Core will support Projects 1 and 2, by performing the viral PCR assays,
which will improve analytical performance and efficiency; and the Data Management Core, by coordinating and
sharing de-identified clinical data.
Specifically, the Core will be responsible for: 1) enrolling infants in the first 6 months of life with influenza or
SARS-CoV-2 infection, as well as healthy non-infected controls, and obtaining sequential blood and respiratory
samples pre and post influenza and COVID-19 vaccination during the first 3 years of life; 2) sample organization
and distribution between Projects (1 and 2); 3) longitudinal clinical data collection, data curation and data
transfer to the Data Management Core for data analyses and integration with all immune assays; 4) measure
influenza and SARS-CoV-2 viral loads by quantitative real-time PCR in clinical samples (nasopharyngeal swabs)
from infants with influenza or SARS-CoV-2 infection. This approach will optimize the use of resources and will
facilitate integration and synergy among all projects.

## Key facts

- **NIH application ID:** 10862557
- **Project number:** 5U19AI168632-03
- **Recipient organization:** ST. JUDE CHILDREN'S RESEARCH HOSPITAL
- **Principal Investigator:** Asuncion Mejias
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $290,923
- **Award type:** 5
- **Project period:** 2022-04-01 → 2027-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10862557

## Citation

> US National Institutes of Health, RePORTER application 10862557, Clinical Core (5U19AI168632-03). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10862557. Licensed CC0.

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