# Data Management Core

> **NIH NIH U19** · UNIVERSITY OF CALIFORNIA-IRVINE · 2024 · $893,398

## Abstract

Project Summary/Abstract – Data Management Core
A well-functioning Data Management Core (DMC) is essential to the success of the UCI Vaccines for Pandemic
Preparedness Center (VPPC). DMC provides shared informatics infrastructures and rigid data integrity oversight
that are key to the quality, efficiency, and cost-effectiveness of VPPC’s data generation and management
processes. DMC also plays an indispensable role in ensuring all digital assets created by VPPC conform fully to
the Findability, Accessibility, Interoperability, and Reusability (FAIR) guiding principles so they can be readily
shared with the scientific community to accelerate discovery and results translation. Such digital assets include
not only the data generated by the Center, but also the associated metadata, documentation, and algorithms
and software code.
 The UCI VPPC DMC, described in this proposal, is committed to working with all VPPC Scientific Cores and
Research Projects to implement a consortium-wide Strategy for Management of Data Activities Plan and
operationalize the strategy through the establishment of data policies, shared informatics infrastructures, and
standard operating procedures (SOP). DMC will also develop automated data transformation and quality control
pipelines to minimize errors and maximize conformity to the data and interoperability standards specified by the
ReVAMPP Coordinating and Data Sharing Center (CDSC). We will work closely with CDSC to ensure high-
quality and timely transfer of data to the ReVAMPP Network, as well as collate information to promptly respond
to inquiries from CDSC or NIAID program staff regarding the Center’s compliance with network-wide timelines
and network data sharing policies.
 The work to be performed by DMC will largely leverage UCI’s existing research computing resources to
reduce redundancy, improve cost-effectiveness, and enable centralized data management and oversight. We
will assist each Scientific Core and Research Project in designing custom informatics solutions optimized for
their data storage and computing needs. We will coordinate with the Administrative Core to deploy software
systems to facilitate consortium-wide project management, and with the Regulatory Science Core to implement
the regulatory-enabling Total Quality Management System (TQMS) at each step of the data lifecycle (i.e.,
acquisition, transformation, storage, analysis, sharing, and archiving) to improve regulatory readiness of our
vaccine candidates to enable rapid response, approval, and deployment. The proposed DMC activities will be
organized under the following 3 specific aims—Aim 1: To provide shared informatics infrastructures to facilitate
centralized management of all data activities of VPPC; Aim 2: To implement standard operating procedures and
automated data transformation and quality control pipelines to ensure data integrity and regulatory readiness;
and Aim 3: To enforce conformity to data and interoperability standards specifie...

## Key facts

- **NIH application ID:** 10863338
- **Project number:** 1U19AI181968-01
- **Recipient organization:** UNIVERSITY OF CALIFORNIA-IRVINE
- **Principal Investigator:** KAI ZHENG
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $893,398
- **Award type:** 1
- **Project period:** 2024-08-20 → 2027-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10863338

## Citation

> US National Institutes of Health, RePORTER application 10863338, Data Management Core (1U19AI181968-01). Retrieved via AI Analytics 2026-06-03 from https://api.ai-analytics.org/grant/nih/10863338. Licensed CC0.

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