# Project 1: Adjuvanted Protein Vaccines for Pandemic Preparedness

> **NIH NIH U19** · UNIVERSITY OF CALIFORNIA-IRVINE · 2024 · $7,511,446

## Abstract

Project Summary/Abstract - Project 1: Adjuvanted Protein Vaccines for Pandemic Preparedness
In preparation for possible future pandemics, our goals for Project 1 are to characterize immune responses and
to develop new adjuvanted multivalent recombinant protein vaccines that are cross-protective within these
target priority virus families with pandemic risk. We will interact closely with other Projects/Cores in the UCI
ReVAMPP program. Each year we will supply Projects 3-5 and Translational Immunology Core with lead
protein vaccine formulations for rodent and non-human primate immunity and challenge models and
transitional human studies, as well as provide a protein microarray for antibody profiling in serum samples from
all projects in the ReVAMPP programs. We will also support Project 2 on formulation and characterization of
mRNA LNP candidates with various lipids, and collaborate with the Regulatory Science Core to ensure the
work performed in this project meets the standards of a quality system allowing the rapid transfer of the
recombinant protein vaccine technologies for their production and further IND-enabling studies. We propose
five Specific Aims: (1) Adjuvant formulation and characterization for recombinant protein vaccines against
Bunyaviruses, Paramyxoviruses and Picornaviruses (2) Immunoprofiling of multivalent recombinant protein
vaccine formulations in rodents via i.m.; (3) To develop the process for the production of six recombinant
protein vaccine antigen candidates against Bunyavirales, Paramyxoviridae, and Picornaviridae. (4) Protein
vaccines for systemic and mucosal immunity. (5) Breadth/durability of multivalent protein vaccine formulations.

## Key facts

- **NIH application ID:** 10863342
- **Project number:** 1U19AI181968-01
- **Recipient organization:** UNIVERSITY OF CALIFORNIA-IRVINE
- **Principal Investigator:** Li Liang
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $7,511,446
- **Award type:** 1
- **Project period:** 2024-08-20 → 2027-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10863342

## Citation

> US National Institutes of Health, RePORTER application 10863342, Project 1: Adjuvanted Protein Vaccines for Pandemic Preparedness (1U19AI181968-01). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10863342. Licensed CC0.

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