# Core E:  Immunogenicity and Immune Correlates Core

> **NIH NIH U19** · WASHINGTON UNIVERSITY · 2024 · $5,024,019

## Abstract

ABSTRACT
Core E: Immunogenicity and Immune Correlates Core (Correlates)
The goal of Core E-Correlates will be to provide support to the projects by conducting various technical
measurements of immunogenicity to enable the establishment of immune correlates of protection for each
prototype virus. We will conduct a comprehensive series of assays to quantitate both humoral and cellular
immune responses in humans and animals for Projects 1-4. Working closely with Core D-Antibody we will
assessing neutralizing antibody responses to down selected monoclonal antibodies. Finally, we will use
predictive and interpretable machine learning to identify immune correlates of protection. Importantly, an
overarching goal of this project is to use these prototype pathogens to identify immune correlates that could be
applied to emerging viruses in the same family with pandemic potential, so we'll assess for similarities in immune
correlates between viruses in the same family and across families for viruses in the same order.

## Key facts

- **NIH application ID:** 10863696
- **Project number:** 1U19AI181984-01
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** Anita K McElroy
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $5,024,019
- **Award type:** 1
- **Project period:** 2024-09-11 → 2027-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10863696

## Citation

> US National Institutes of Health, RePORTER application 10863696, Core E:  Immunogenicity and Immune Correlates Core (1U19AI181984-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10863696. Licensed CC0.

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