# MENTORED PATIENT-ORIENTED RESEARCH TOWARDS OPTIMIZING CARDIOVASCULAR OUTCOMES IN CHRONIC KIDNEY DISEASE

> **NIH NIH K24** · BAYLOR COLLEGE OF MEDICINE · 2024 · $117,640

## Abstract

PROJECT SUMMARY
This application is for a K24 Midcareer Investigator Award in Patient-Oriented Research for Dr. Sankar
Navaneethan. He is a Professor of Medicine and Director of Clinical Research in the Section of Nephrology, at
Baylor College of Medicine. Dr. Navaneethan’s research projects have focused on improving cardiovascular
and kidney outcomes for those with and at risk of chronic kidney disease (CKD). He has extensive experience
in epidemiological investigations, clinical trials, and systematic reviews. Over the past decade, he has
mentored trainees at different levels including medical students, residents, fellows, and junior faculty on
various patient-oriented research studies. Current proposal would help him achieve following goals: a) dedicate
additional time to mentor young investigators in various patient-oriented research projects related to
cardiovascular disease in kidney disease, b) learn new skills in mentoring skills through both formal courses
and workshops and interactions from mentors within and outside his institution, c) enhance ongoing patient-
oriented research activities in obesity and impact of other metabolic diseases on cardiovascular disease in
CKD population, d) to identify new scientific areas of patient-oriented research that are critical to improvement
in cardiovascular outcomes of CKD population, and e) to develop leadership skills. Proposed research projects
by the applicant over the 5-years would help understand the uptake of and barriers in the adoption of cardio-
kidney protective medications among those with kidney disease and investigate the potential role of sodium-
glucose cotransporter-2 inhibitors (SGLT2i) in improving outcomes of those with pulmonary hypertension.
These projects would utilize and expand PI’s current research infrastructure and provide data for future
interventional studies. Aim of the first project is to study the pattern of initiation and uptake of SGLT2i and
glucagon-like peptide-1 receptor agonists (GLP-1RA) among those with kidney disease using data collected
from the Veterans Affairs health system. Objectives of the second project is to conduct a pilot non-randomized
study to examine the effects of SGLT2i on pulmonary artery pressure in those with CKD.

## Key facts

- **NIH application ID:** 10863911
- **Project number:** 5K24HL161414-03
- **Recipient organization:** BAYLOR COLLEGE OF MEDICINE
- **Principal Investigator:** Sankar Dass Navaneethan
- **Activity code:** K24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $117,640
- **Award type:** 5
- **Project period:** 2022-07-15 → 2027-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10863911

## Citation

> US National Institutes of Health, RePORTER application 10863911, MENTORED PATIENT-ORIENTED RESEARCH TOWARDS OPTIMIZING CARDIOVASCULAR OUTCOMES IN CHRONIC KIDNEY DISEASE (5K24HL161414-03). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10863911. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*