The Center for Advancing Sociodemographic and Economic Study of Alzheimer’s Disease and Related Dementias (CeASES ADRD), established in 2020 at the University of Southern California, is a leader in fostering a broad network of social science researchers and driving innovative health policy and economic research on dementia to improve individual and societal well-being. Through innovative programming, research and communication for impact, CeASES ADRD built a network of over 300 research affiliates, collaborated with 8 NIH-funded centers to produce 12 workshops and webinars, hosted 8 visiting scholars, fostered 5 collaborative NIA grants, funded 17 pilot studies that led to 14 R applications submitted to NIA, 5 funded R01s and produced numerous high impact publications. Activities proposed in the current renewal application will build on our strengths and move research forward, through growing and deepening research networks and convenings, supporting early stage scholars through pilot awards coupled with transformative mentorship, developing and supporting new data resources, integrating advanced methods from computer science into social science dementia research, and building the model infrastructure for leveraging the large and growing number of harmonized global aging studies to address central questions about the causes and consequences of dementia. Effective leadership will connect core activities and link NIA resources across our partner centers and other NIA funded Aging Centers. New web-based, interactive portals, and adoption of new technologies such as computer emulation will expand impact to research, policy and public audiences. We will move innovative ADRD health policy and economics research forward across four research themes: (1) estimating social and economic impact of AD/ADRD; (2) improving healthcare payment and delivery systems; (3) promoting value and access to quality dementia care; (4) addressing the global dementia burden through dynamic microsimulation models. To do so, CeASES ADRD brings data, programming and external affairs resources from the USC Schaeffer Center for Health Policy and Economics and the policy impact resources from the new Schaeffer Institute together with our 11 NIA-funded Partner Centers including USC’s Resource Center for Minority Aging Research, Alzheimer’s Disease Research Center, Roybal Center, Gateway to Global Aging Data, and Gateway Exposome Coordinating Center. Multidisciplinary researchers from across schools of policy, gerontology, medicine, engineering, arts and sciences at the University of Southern California and the University of Texas, Austin weave together strengths in innovative dementia research, mentorship, rigorous dynamic microsimulation, quasi-experimental and machine learning methods, and application of myriad population level, longitudinal data sets to generate impactful AD/ADRD social science research.