# The impact of genetic and environmental factors on meiotic prophase in the human female

> **NIH NIH R01** · WASHINGTON STATE UNIVERSITY · 2024 · $347,167

## Abstract

PROJECT SUMMARY
Meiotic studies of human fetal ovaries we conducted for over a decade have generated the largest
available human female meiotic database. This unique resource includes matched maternal/fetal
biospecimens for each sample collected from 2008 to 2017, a period of rapid changes in both the
spectrum and levels of endocrine disrupting chemical (EDC) contaminants. The proposed studies
will test the hypothesis that the high meiotic error rate in the human female is driven by both an
innate propensity to error (e.g., due to the protracted nature of female meiosis and differences in
cell cycle control) and environmental factors. We postulate that environmentally-induced effects
will be discernable because they disturb well-defined meiotic relationships. We will expand our
meiotic database for the cohort and characterize the features of a well-known cause of human
aneuploidy, recombination failure. Meiotic profiles for each case in conjunction with exposure
profiles will be used to determine if and how fetal exposure affects the early stages of female
germline development in humans. We also will obtain data on temporal changes in human
exposure to common endocrine disrupting chemical (EDC) contaminants and compare the ability
of different EDCs to transit from the maternal circulation to the developing fetus.

## Key facts

- **NIH application ID:** 10864006
- **Project number:** 5R01HD108165-03
- **Recipient organization:** WASHINGTON STATE UNIVERSITY
- **Principal Investigator:** TERRY J HASSOLD
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $347,167
- **Award type:** 5
- **Project period:** 2022-09-22 → 2026-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10864006

## Citation

> US National Institutes of Health, RePORTER application 10864006, The impact of genetic and environmental factors on meiotic prophase in the human female (5R01HD108165-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10864006. Licensed CC0.

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