# Administrative Core

> **NIH NIH P30** · YALE UNIVERSITY · 2024 · $150,988

## Abstract

The theme of the Yale/NIDA Neuroproteomics Center, “Proteomics of Altered Signaling in Addiction”,
follows from the premise that exposure to drugs of abuse usurps regulation of intracellular signaling processes
in brain reward Centers that in turn alters gene expression, protein translation, and post-translational
modifications of proteins. Repeated exposure to drugs of abuse results in stable alterations in these signaling
systems that are critical for the changes in brain chemistry and development of the structure of the addicted
brain. The major goal of the Center is to bring together exceptionally strong programs from Yale and 8 other
non-Yale institutions in proteomics, signal transduction, and drug addiction research to create a synergistic,
virtual environment that uniquely leverages existing resources and our ability to successfully compete for future
resources (e.g., instrumentation funding via NIH SIGs) to characterize neuronal signaling processes and to
identify adaptive changes in protein signaling that occur in response to exposure to drugs of abuse.
 The Administrative Core will play an essential role in the organization and operation of the
Neuroproteomics Center. Among its tasks will be to recruit for the Center's research base the very best
investigators in the field; ensure the Cores have sufficient space, the best possible instrumentation and staff,
ITS and infrastructure support, and are responsive to and are continuously developing innovative solutions to
optimally meet the biotechnological needs of the Center's investigators and pilot project grantees; promote
interactions among the investigators and scientific cores; and ensure that the Center maintains its focus on its
theme and actively engages in training and education.
 The Specific Aims of the Administrative Core will be to: 1. Administer the Yale/NIDA Neuroproteomics
Center; 2. Administer, support, and coordinate the activities of the Research Support Cores and optimize their
use by Center investigators; 3. Optimize overall operation of the Neuroproteomics Center and its interactions
with other Centers and organizations; and 4. Oversee the training mission of the Neuroproteomics Center.
 Through its interdisciplinary and collaborative organization, the Administrative Core will bring highly
qualified signal transduction and drug addiction researchers into the Center so that proteomic specialists can
utilize their rapidly evolving tools to gain understanding of the mechanisms of actions of drugs of abuse. They
will be supported by an extensive array of instrumentation and highly trained staff that will allow members of
this Center to optimally bring the most powerful proteomic technologies to bear on the study of the proteomic
changes that occur in response to drugs of abuse.

## Key facts

- **NIH application ID:** 10864015
- **Project number:** 5P30DA018343-20
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** Kenneth Robert WILLIAMS
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $150,988
- **Award type:** 5
- **Project period:** 2004-07-01 → 2025-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10864015

## Citation

> US National Institutes of Health, RePORTER application 10864015, Administrative Core (5P30DA018343-20). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10864015. Licensed CC0.

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