Project Summary/Abstract The Cellular, Biochemical, and Molecular Sciences (CBMS) Training Program at Vanderbilt University provides a unique educational and training experience for a diverse group of graduate students spanning multiple departments and disciplines in the School of Medicine and the College of Arts and Science. The mission and objectives are to train the next generation of scientific leaders in critical thinking, experimental skills, and communication/teamwork skills necessary for productive careers in modern biomedical sciences. Laboratory training and cutting-edge research remain the core of the program, complemented by structured didactic training in each discipline, as well as ongoing mentoring, training in Responsible Conduct in Research, Rigor and Reproducibility, career counseling, and leadership and communication skills. The CBMS Training Program serves a unique role in interdisciplinary graduate training at Vanderbilt by embracing a large preceptor list that spans 11 different departments and programs. We emphasize broad-based, basic, interdisciplinary research encompassing labs that study a range of topics, complementing other training programs at Vanderbilt that are more discipline specific. Our program promotes intellectual exchange within the biomedical community at the intra- and inter-laboratory levels. We conduct the only university-wide, weekly journal club providing high level scientific presentations across disparate fields from leading researchers in each area. Trainees also participate in dedicated sessions providing opportunities for oral research presentations, responsible conduct in research, rigor and reproducibility, career training, and two dedicated courses---Experimental Design, and Maximizing Your Potential: Leading and Managing Organizations, Teams, and your Career. Diversity is a major goal of the CBMS training program at Vanderbilt, not only diversity among our trainees, but diversity among research areas pursued by each trainee. Since no one knows with certainty which areas of modern biomedical science will be required in the next 10 years, it is essential to educate a diverse set of future researchers and leaders in a broad fashion so that they will be well positioned to capitalize on new findings and poised to succeed in unforeseen areas.