# Neuropathology Core

> **NIH NIH P30** · MAYO CLINIC ROCHESTER · 2024 · $230,190

## Abstract

PROJECT SUMMARY – NEUROPATHOLOGY CORE
The Neuropathology (NP) Core performs diagnostic evaluations, quantitative analyses on brain tissue collected
at autopsy of participants in the Mayo Alzheimer Disease Research Center (ADRC), allowing feedback to
clinicians, closure to family members and contribution to research by providing scientists postmortem brain
samples and data derived from those samples. The NP Core provides support to ADRC-affiliated investigators
and to outside investigators. The neuropathologic and genetic data are communicated to the Data Management
and Statistical Core, who uploads it to the National Alzheimer Coordinating Center (NACC). The research
approach for the NP Core is as follows: Specific Aim 1. Perform brain autopsies on a diverse population of
participants of the Mayo ADRC in a timely fashion and according to protocol, which includes collection of fixed
and frozen tissue, postmortem CSF and demographic and clinical data related to these samples. Specific Aim
2. Provide neuropathologic evaluations and collect neuropathologic data using standardized methods for gross
dissection and neurohistology. Assign AD likelihood diagnoses based upon Thal amyloid phase, Braak NFT
stage, and CERAD neuritic plaque score using the NIA-AA ABC diagnostic probability scheme. Arrive at a
consensus on clinicopathologic diagnoses and educational opportunities at videoconferences. Record
neuropathologic data with NACC Version 11 and provide data to the Data Management and Statistical Core
and NACC. Specific Aim 3. Generate quantitative endophenotypes using digital pathology and image analysis
in support of ADRC research. Specific Aim 4. Store brain fixed and frozen tissue and other autopsy-derived
materials and provide clinically and pathologically well-characterized tissue samples to investigators at Mayo
Clinic and outside institutions supporting biochemical and biomarker discovery. Frozen tissue is continuously
monitored by an electronic system and available backup freezers to ensure high-quality sample preservation.

## Key facts

- **NIH application ID:** 10865854
- **Project number:** 2P30AG062677-06
- **Recipient organization:** MAYO CLINIC ROCHESTER
- **Principal Investigator:** DENNIS WILLIAM DICKSON
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $230,190
- **Award type:** 2
- **Project period:** 2019-07-01 → 2029-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10865854

## Citation

> US National Institutes of Health, RePORTER application 10865854, Neuropathology Core (2P30AG062677-06). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10865854. Licensed CC0.

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