PROJECT SUMMARY - OUTREACH, RECRUITMENT AND ENGAGEMENT CORE The Mayo Clinic Alzheimer’s Disease Research Center (ADRC) Outreach, Recruitment, and Engagement (ORE) Core serves as a bridge between ADRC scientific advances and the needs of study participants, caregivers, and the communities we serve across two distinct geographical regions in Rochester, MN and Jacksonville, FL. The ORE Core supports ADRC projects, related studies, and national Alzheimer’s Disease and Related Disorders initiatives. The primary aim of ORE Core is to engage, recruit, and retain ADRC study participants from socially underserved and ethnoracially underrepresented groups who are at disproportionate risk for Multiple Etiology Dementia and dementia-related health disparities. We will focus recruitment efforts specifically on persons from African American/Black (AA), Hispanic/Latino (HL), and Rural Dwelling (RD) communities (Aim 1). To accomplish this, we will implement and evaluate innovative methods of community- based outreach, engagement, and research participation in the communities we serve (Aim 2); advance the science of diverse recruitment by identifying barriers and evaluating solutions to enhance study enrollment (Aim 3); and engage in dementia care research evaluating novel technology-based solutions to address unmet caregiver needs (Aim 4). We will assess structural and social determinants of health across all aims and identify opportunities to ensure ADRC cohorts reflect the communities we study. Our success in achieving Core aims will be facilitated through collaboration with community partners who will help us understand the needs of community members. We will partner with ADRC Clinical, Biomarker, Genomics, Neuropathology, and Digital Innovation Core investigators to help inform the content of educational materials and programs to meet those needs and engage community advisors to ensure materials and programs are culturally and linguistically appropriate.