PROJECT SUMMARY– NEUROIMAGING CORE Neuroimaging Core will support the Mayo Clinic ADRC with standardized operating procedures for neuroimaging in Mayo Clinic Rochester (MCR) and Mayo Clinic Florida (MCF) and promote the applications of advanced imaging technology in the Alzheimer’s disease (AD) and AD-related dementias (AD/ADRD) for the evaluation of multiple etiology dementia. The goal of the Neuroimaging Core is to provide imaging biomarker data for diagnostic classification and staging of AD/ADRD, for research projects and clinical trials on ADRC participants through a harmonized multimodality neuroimaging program at the MCR and MCF sites, designed to support the overarching theme of the ADRC: “Multiple Etiology Dementias.” The Neuroimaging Core will provide innovative technology and resources for understanding the pathologic processes contributing to neurodegeneration and cognitive impairment through multimodal imaging, for individualized imaging biomarker-based diagnosis considering sex as a biological variable, ethnicity, race, additional structural and social determinants of health, and genetic-risk. The aims of the Neuroimaging Core include: 1) Establish and maintain a harmonized MRI, DaTscan SPECT, β-amyloid, tau, and FDG PET imaging program for Mayo Clinic ADRC MCR and MCF sites, and operate a standardized quality control, image processing, and data analysis program for the ADRC cohorts including the African American/Black and Hispanic/Latino Cohorts in MCF; 2) Support imaging studies, share ATN and other imaging biomarker data on multiple dementia etiologies (AD, Lewy bodies, vascular) with the ADRC Data Core, affiliated research projects and clinical trials, and the National Alzheimer’s Coordinating Center (NACC), while protecting patient confidentiality when sharing high-resolution images using novel defacing approaches; 3) Provide leadership and education in neuroimaging within the ADRC research community and support development, utilization, and sharing of neuroimaging biomarkers in AD/ADRD. Neuroimaging Core will collaborate with the Clinical Core and the Outreach, Recruitment and Engagement (ORE) Core on recruitment of clinically characterized rural dwelling, Hispanic/Latino and African American/Black participants to imaging studies, with the Biomarker Core for correlating the fluid biomarkers with the imaging findings, with the Neuropathology Core for autopsy confirmation of imaging findings associated with multiple etiologies, with the Data Management and Statistical Core to share imaging biomarker data with the Genomics Core and Digital Innovation Core, and with the Research Education Component (REC) on training early-stage investigators on imaging biomarkers.