# Genomic Core

> **NIH NIH P30** · MAYO CLINIC ROCHESTER · 2024 · $330,659

## Abstract

PROJECT SUMMARY – GENOMICS CORE
The Mayo Clinic Alzheimer’s Disease Research Center (ADRC) and its related activities resulted in seminal
contributions to the genomics of AD and related disorders (ADRD) since 1990. These include identification of
AD genetic risk factors using endophenotype approach, discovery of familial mutations that cause frontotemporal
lobar degeneration (FTLD) and/or amyotrophic lateral sclerosis (ALS), and genome-wide association studies
(GWAS) of AD, Lewy body spectrum disorders (LBD) and FTLD/ALS. Mayo Clinic ADRC contributes to systems
biology studies which integrate multi-omics and patient endophenotypes to discover novel therapeutic targets
and biomarkers for ADRD and molecular underpinnings for vascular contributions to cognitive impairment and
dementia (VCID). These studies are conducted under the NIH-NIA consortia, AMP-AD, M2OVE-AD, Resilience-
AD, and CLEAR-AD in which Dr. Nilüfer Ertekin-Taner, the Director of the proposed ADRC Genomics Core,
serves as PI. Mayo Clinic ADRC samples are widely shared internally or externally. These samples undergo
characterizations including screening for disease/risk variants providing study inclusion criteria. These extensive
core-type activities continued with piecemeal funding for >15 years, given lack of a Mayo Clinic ADRC Genomics
Core. This proposal aims to establish a Genomics Core with the overarching objectives to a) centralize and
standardize these activities to meet the needs of Mayo Clinic ADRC and external investigators and b) support
innovative studies leveraging the rich collection of samples to discover genomic basis of the Multiple Etiology
Dementias. We expect the proposed Genomics Core to successfully streamline the genomic sample
management (Aim 1) and their multi-omics molecular characterizations (Aim 2); to determine the association
between these multi-omics measures and the exposome (Aim 3) and to share these outcomes broadly (Aim 4).
Our diverse Core Leadership and all aims are aligned with the PEDP. Our aims are to: Manage samples for
genomic analysis: We will standardize and centralize the DNA/RNA extraction, QC, internal/external distribution
and data management of the samples. Perform systematic multi-omics molecular profiling of Mayo Clinic ADRC
samples: We will perform genomic characterizations of samples from all ADRC participants including AD, FTLD
and LBD spectrum diagnoses using both existing (GWAS/WGS) and new molecular data (RNA/methylation).
Determine the association of exposome and multi-omics measures: Exposome including but not limited to
structural and social determinants of health (SSDoH) will be curated and included in innovative analyses. Share
data, algorithms, and summary outcomes with the ADRC and the research community: This will be accomplished
by collaborations with the NACC and NIA-approved data repository AD-Knowledge Portal. In summary, the
proposed ADRC Genomics Core will oversee the essential functions of genomics sample manage...

## Key facts

- **NIH application ID:** 10865859
- **Project number:** 2P30AG062677-06
- **Recipient organization:** MAYO CLINIC ROCHESTER
- **Principal Investigator:** NILUFER ERTEKIN-TANER
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $330,659
- **Award type:** 2
- **Project period:** 2019-07-01 → 2029-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10865859

## Citation

> US National Institutes of Health, RePORTER application 10865859, Genomic Core (2P30AG062677-06). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10865859. Licensed CC0.

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