PROJECT SUMMARY: ENRICHMENT PROGRAM The overall objective of the Enrichment Program is to enhance the C-SiG environment by promoting education and fostering research synergy through communication amongst its members. To do this, we pursue five complementary SPECIFIC AIMS to: i) Support an infrastructure of electronic communication including internal and external C-SiG Web sites and a weekly email newsletter of C-SiG announcements and relevant seminars; ii) Conduct a monthly Center-wide seminar series, 3 monthly mechanistic research theme seminar series (i.e. intracellular signaling, cellular networks, genetics and epigenetics), and 6 regular journal clubs; iii) Organize an annual scientific Minisymposium and an annual workshop topical to the center mechanistic themes; iv) Facilitate extramural collaboration and technology transfer by leveraging expertise at other institutions, including other NIDDK-funded DDRCCs via a Mini-Sabbatical Program; and v) Nurture junior investigators by supporting an annual research career development retreat, an Early Career Development and Research Training Program, and the newly developed Computational Biology educational resources; vi) Integrate Pilot and Feasibility awardees and other junior faculty in leadership roles (e.g. speaker selection and hosting, moderating, etc.). In addition, the Enrichment Program will continue to plan and organize one annual conference every 5 years for the Midwest DDRCC Alliance (Mayo, Case Western University, University of Chicago, University of Cincinnati, and Washington University). C-SiG has been awarded an R13 grant to partially support the next conference, which we will host in Rochester, MN on Oct 26-28, 2023.