Religion is a primary driver of concerns with genomics and genomic healthcare (GGH). It is vital for research on the ethical, legal, and social implications (ELSI) of genomics to understand the role of religion in shaping public attitudes toward GGH. Ninety percent of the US public believes in some kind of higher power and 55% pray daily. The US public attends religious services at a rate 3 times higher than scientists in the US, who are at risk of misunderstanding the role religion plays in attitudes toward GGH. Further, Black, Hispanic, and rural populations attend religious services more frequently than the general US public. Concerns with GGH activities may lead to lower levels of engagement of GGH, which may in turn contribute to health disparities. This project aims to understand why higher levels of religious practice are associated with greater concerns with GGH activities. Additionally, this project will interview faith leaders to identify how public health genomics might engage faith communities in ways that are respectful and constructive. While some concerns with healthcare technologies may disappear with new information, others stem from worldviews, deep moral commitments, or mistrust of the healthcare system. Engaging religious communities is essential to identify which concerns can be addressed with information, which call for alternative responses, and what alternative responses might look like. Very few models exist for genomic public health engagement with religion, particularly models that directly address value-laden concerns.13,14