PROJECT SUMMARY Increasingly, genomics is being integrated into population-level cancer prevention and control approaches through precision public health. Given that the field is still emerging, there are limited opportunities for investigators to come together to form collaborations and to build capacity for research. Thus, our goal for this R13 renewal application is to convene an annual transdisciplinary conference for investigators who work in this field to support capacity building in transdisciplinary precision public health research, with a focus in cancer over the next three years. Our target audience emphasizes engaging early career investigators in cancer precision public health who are in a pivotal moment in their career for establishing professional networks and identifying research priorities. Our specific aims for the conference are to (1) increase content knowledge and methods expertise in cancer precision public health through seminars and question and answer sessions; (2) advance research priorities for cancer precision public health; and (3) maintain an ongoing professional network of precision public health researchers in cancer to facilitate future collaborations in precision public health research, training, and practice. Through this international conference, investigators from around the world will convene annually to gain new content expertise, to advance key research priorities for the field, and to establish an ongoing collaborative network to advance precision public health research. This builds on the work of our inaugural conference which established key research priorities, an ongoing working group to advance these priorities, and a network of precision public health researchers and practitioners who meet quarterly for webinars on advanced topics in precision public health in cancer. Moreover, the conference themes will reflect the research priorities identified in the 2021 conference: implementation science (2023 at University of North Carolina Chapel Hill), health equity (2024 Medical University of South Carolina) and capacity building (2025 University of Technology Sydney). Our long-term goal is to maintain a platform for early career investigators interested in precision public health to come together to support the development of the precision public health research agenda.