PROJECT SUMMARY - CARE RESEARCH CORE (CORE H) Rigorous research on Alzheimer’s disease (AD) care to improve outcomes encompasses intensive investigations on care contexts, care partners, models of care, and a variety of interventions designed to improve disease management and outcomes for persons with AD and related dementias and their care partners. As one of the few geriatrics-based ADRCs, the Wisconsin ADRC has a strong track record of developing and supporting rigorous care-focused AD research, launching the first ‘AD Care Research Core (Core H)’ in the past renewal cycle (2019). Since then, Core H has successfully met its initial objectives, 1) recruiting a registry of well- characterized patients across all stages of AD and their care partners and establishing a linkage with health record data; 2) growing infrastructure across a variety of clinical systems to facilitate translational AD care research; and 3) supporting development of a rich array of multi-disciplinary consultant expertise spanning all facets of care research and, particularly, AD-disparities aligned social exposome inquiry as a key resource leveraged by the full ADRC network. Core H remains systematically integrated with other Cores, offering an unparalleled opportunity to investigate highly innovative, rigorous research questions that straddle the fields of AD biomarkers, diagnostics, and clinical care. Core H will continue to support new collaborations focusing on diverse settings that span the continuum of AD care from diagnosis to advanced disease. Specific Aims are: Aim 1: Care Research Infrastructure: 1a) Continue to provide and diversify ready collaborations with “research ready” clinical settings to facilitate AD care-focused research to advance the development and testing of care approaches across diverse settings and populations reflective of the full spectrum of AD care priorities; 1b) Strategically expand the established Care Core Registry of individuals with AD and their care partners to address under-studied care contexts/settings in the dementia care process and provide opportunities for plasma biomarker (Core G) and brain donation (Core D); 1c) Maintain electronic health record linkages to existing well- characterized ADRC subject cohorts and merge with AD biomarker (plasma, CSF, neuroimaging) and cognition data. Aim 2: Context of Care (Exposome) Research Infrastructure: Advance integration of AD-disparities aligned social exposome approaches pertinent to the study of AD disease processes, management, and receipt of care across the ADRC network through continued investment in aligned Core H resources. Aim 3: Methodology, Training, and Consultation: 3a) Develop and nationally disseminate resources for AD care and care partner research engagement; 3b) Provide training to UW-Madison investigators and staff on AD care research methods; 3c) Provide pre- and post-award consultation to investigators implementing and/or planning AD care research studies and assist i...