# Core H: Latino Core

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $417,963

## Abstract

Alzheimer’s disease and related dementias (ADRD) among U.S. Latinos are projected to increase over
nine-fold from 379,000 in 2012 to 3.5 million by 2060. Latinos represent 18% of the U.S. population and almost
twice that number in California. Latinos lag behind Whites and African-Americans in education and healthcare
insurance, and have cardiovascular, metabolic, and other disease burdens that exceed those of Whites;
however, Latino life-expectancy at birth surpasses that of Whites by over 3-years giving them greater exposure
to age-related risk of ADRD. Though they have greater life-time risk, Latinos are less likely to present for
possible diagnosis and intervention because of cultural differences in reporting behavioral, cognitive, and
functional deficits. Furthermore, they are less likely to be diagnosed accurately because methods used to
diagnose AD were largely developed and validated in relatively homogeneous, well-educated, White, English-
speaking populations, including state-of-the-art clinical, neuropsychological, and neurological procedures
which may not work effectively with monolingual Spanish-speaking or Spanish-English bilingual older Latinos.
Thus, there is a need for AD-related research in older Latinos to overcome barriers to effective screening,
assessment, diagnosis and treatment of early and preclinical disease. There is also a need to better
understand factors that impede or facilitate participation of older Latinos in AD-related research, including
awareness of AD and its clinical features, level of concern about the consequences of AD and burden of care,
and willingness to participate in research including procedures such as sampling of biomarkers, genetics, and
autopsy. To address these needs, the overall aims of the Latino Core are to develop methods, tools and
strategies to 1) improve clinic and community-based memory screening in support of better health care for
Latinos with ADRD and their recruitment into the ADRC Clinical Core cohort and volunteer registry, 2) improve
objective neuropsychological assessment for detecting and tracking preclinical AD, MCI and the transition to
AD in older Latinos, and to develop new tests and refine existing tests for these purposes, and 3) improve
acquisition and interpretation of self-reported cognitive decline, language proficiency, degree of bilingualism,
and attitudes towards ADRD research participation. The Latino Core will ensure that the ADRC is well
positioned to study ADRD in this significant yet underserved portion of the population, filling critical gaps in
scientific knowledge essential for reducing the disparities related to ADRD diagnosis, treatment and care facing
Latinos in our San Diego community and beyond. Systematic study of AD in this diverse group will lead to
unique insights and improved understanding of the consequences of AD in general (in all populations).

## Key facts

- **NIH application ID:** 10867183
- **Project number:** 2P30AG062429-06
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** Tamar Gollan
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $417,963
- **Award type:** 2
- **Project period:** 2019-05-01 → 2029-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10867183

## Citation

> US National Institutes of Health, RePORTER application 10867183, Core H: Latino Core (2P30AG062429-06). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10867183. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*