Candidate: Chio Yokose, MD, MSc is an Instructor in Medicine at Harvard Medical School (HMS) and an Assistant in Medicine in the Division of Rheumatology, Allergy, and Immunology at Massachusetts General Hospital (MGH). After graduating Brown University magna cum laude with her BA in Biology and East Asian Studies, she received her MD from Northwestern University. She completed her internal medicine residency at New York University and her rheumatology fellowship at MGH. She also received her MSc in Epidemiology from the Harvard T.H. Chan School of Public Health. Dr. Yokose conducts patient-centered research focused on gout and its cardiometabolic comorbidities under the mentorship of Hyon Choi, MD, DrPH. Her research has resulted in 17 peer-reviewed original manuscripts (eight as first-author). Her goal is to become an independent investigator and leader in personalized, patient-centered gout research. Mentorship, Training Activities, and Environment: Dr. Yokose will conduct the proposed project at MGH under the mentorship of Hyon Choi, MD, DrPH and co-mentorship of David W. Bates, MD, MSc and Maria Edelen, PhD. Dr. Choi is a world-renowned, NIH-funded physician investigator with expertise in advanced epidemiologic methodologies and risk factors for incident gout. Dr. Bates is a preeminent expert on leveraging medical informatics to conduct patient safety, quality, and clinical effectiveness research. Dr. Edelen has extensive expertise in the development, implementation, analysis, and interpretation of patient-reported outcomes measures (PROMs). Drs. Choi, Bates, and Edelen all have extensive experience mentoring trainees and junior faculty, including multiple prior K awardees. Dr. Yokose will also benefit from the specific expertise of her key collaborators, including pharmacoepidemiology methods and latent class analysis. Under the guidance of her mentorship team, she will acquire skills in new research areas including comparative effectiveness research, research using real-world data, and patient-centered outcomes research using biomarkers and PROMs. Research: The morbidity and mortality burden of gout and its cardiometabolic comorbidities continues to rise. These trends highlight the limitations of our current gout care model in which gout and comorbidities are managed independently. The central goal of this research is to examine the gout benefits of pleiotropic cardiometabolic medications and identify a framework for the personalized integration of gout and comorbidity care to synergistically address gout and comorbidities and ultimately improve outcomes for patients with gout. To achieve this, Dr. Yokose will conduct rigorous comparative effectiveness research examining the serum urate- lowering potential of common cardiometabolic medications (Aim 1) and determine comorbidity phenotypes of incident gout and their relations with serum urate change (key causal precursor to gout) and PROMs related to gout care barriers (Aim 2). By completing...