# Core B - Clinical Core

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $1,080,288

## Abstract

PROJECT SUMMARY
The overarching goal of the Clinical Core is to establish and maintain clinical research infrastructure that
provides deep phenotyping and longitudinal characterization of clinically and ethnoculturally diverse research
participants for the local and wider research communities. Initially funded in 2004, the longstanding central
theme of this ADRC is atypical and early age-of-onset cases and is one of few centers to focus on
frontotemporal dementia, early-onset/atypical Alzheimer’s disease, prion, and now traumatic encephalopathy
syndrome. Chinese and Latino Americans are substantially and meaningfully represented, in alignment with
San Francisco demographics. Participant heterogeneity is deeply characterized using precision medicine tools
to clarify the phenotypes of AD/ADRD molecular subtypes, predictors of disease trajectories, and the neural
bases of cognition and behavior. Cognitive assessments and care models with real-world applicability for early
detection and diagnosis are validated in the Core and extended to real world clinical practice to address major
gaps in care. Core data and participants are readily shared to support impactful AD/ADRD research at UCSF
and beyond. Core faculty offer multidisciplinary mentorship, clinical research rotations, and infrastructure for
carrying out multi-dimensional AD/ADRD research to a large and diverse group of trainees. The Clinical Core
works in close collaboration with all other Cores and serves a central and unifying role in the ADRC. The aims
of the Clinical Core are to: 1) Perform longitudinal evaluation of functionally-intact normal controls, participants
with mild cognitive impairment or mild behavioral impairment, Alzheimer’s dementia, frontotemporal dementia-
spectrum disorder, traumatic encephalopathy syndrome, and prion disease. 2) Carry out innovative and deep
phenotyping to characterize our participants’ clinical presentations and their longitudinal trajectories. 3) Provide
clinical data and well characterized participants for research on aging and dementia to the larger research
community. 4) Support research training. With this renewal, neuropsychologist Katherine Possin, PhD will
assume the role of Core Lead, supported by neurologist Gil Rabinovici, MD and senior advisor Joel Kramer,
PsyD.

## Key facts

- **NIH application ID:** 10868118
- **Project number:** 2P30AG062422-06
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Katherine Laurel Possin
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $1,080,288
- **Award type:** 2
- **Project period:** 2019-05-01 → 2029-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10868118

## Citation

> US National Institutes of Health, RePORTER application 10868118, Core B - Clinical Core (2P30AG062422-06). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10868118. Licensed CC0.

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