PROJECT SUMMARY/ABSTRACT We are requesting funds for a NanoString CosMx Single Molecule Imager (SMI) to support spatial -omics in the Institute of Genomic Medicine (IGM) Genomics Center at the University of California, San Diego (UC San Diego). The CosMx SMI will be placed in the IGM Genomics Center, a campus-wide core facility managed by the IGM. The highly trained staff of the Genomics Center are experienced with cutting edge genomics technologies, skills which will translate well to spatial-omics. Since the IGM Genomics Center was established in 2013, we have provided access to genomics technologies to the UC San Diego community, consistently upgrading equipment and services to keep pace with the latest innovation in the field. Both our team and our users are excited about spatial -omics technologies, and we are committed to providing access to this cutting- edge workflow to campus. The IGM Genomics Center supports the genomics research of 290 NIH-supported investigators from UC San Diego, as well as neighboring institutions, in the areas of basic, translational, and clinical biomedical research. We have identified 10 Major and Minor Users across the UC San Diego research community, including investigators from nine different departments The projects of our Users encompass multiple areas of relevance to human health including retinal disease, inflammatory bowel disease, wound healing, neurobiology, immunology, neural degeneration and reproductive science. The data generated on the CosMx SMI has the potential to uncover novel disease mechanisms and potential new treatments for disease. UC San Diego has demonstrated a strong commitment to the advancement of genomics research and the IGM Genomics Center is determined to continue to provide cutting edge technologies and technical expertise to the local research community. With the support of our institution and our qualified staff, we will ensure that the CosMx SMI is properly maintained and used to its full potential.