# Overall: Resource-based Center for Musculoskeletal Disorders Research (Overall Application)

> **NIH NIH P30** · UNIVERSITY OF PENNSYLVANIA · 2024 · $895,284

## Abstract

The Penn Center for Musculoskeletal Disorders (PCMD) will continue to provide critical resources and
programs to, and enhance research productivity of, investigators to address multidisciplinary research
strategies for musculoskeletal problems. The overall goal of this Center is to promote cooperative interactions
among investigators, accelerate and enrich the effectiveness and efficiency of ongoing research, foster new
collaborations and new research, and ultimately, translate our research efforts into better and new therapies for
musculoskeletal disorders. The Center theme is “Musculoskeletal Development, Disease, Injury and Repair”
while addressing 3 Research Thrust areas. Our PCMD is the home for musculoskeletal research across the
Penn campus and a hub for the musculoskeletal community across the region and neighboring states .
 One focus of our Center is to bridge themes, approaches, and paradigms across musculoskeletal tissues
which may be overlooked when studying a single tissue. Since approaches used to evaluate mechanisms in
one tissue could aid researchers in other areas, our Center will foster this critical cross-talk. To further focus,
we will emphasize small animal models utilizing unique and sophisticated methods that cross length scales.
The PCMD will provide unique expertise and tools to investigate musculoskeletal tissues across such scales.
 Thus, the primary overall Aims of this Center remain to enhance and advance the research productivity of
investigators in musculoskeletal development, disease, injury and repair by providing: Aim 1: Innovation within
critical resource core facilities in areas that cross disciplines, length scales, and hierarchies. These core
facilities remain µCT Imaging, Biomechanics, and Histology; Aim 2: A pilot and feasibility grant program, with
direct mentorship; and Aim 3: Educational and research enrichment programs, through which members can
learn from national leaders and from each other. High quality musculoskeletal research is being conducted by
many groups at Penn, in the region, and neighboring states. While many bring sophisticated approaches to
musculoskeletal problems, few have the required expertise and facilities to perform the broad range of rigorous
and specialized assays in their own labs. The Center will provide opportunities to integrate techniques to define
mechanisms for tissue function, injury, development, degeneration, repair, and regeneration, with the ultimate
goal of advancing diagnosis, treatment, and prevention of diseases and injuries of the musculoskeletal system.
There is also an intangible feature of our Center. Although our musculoskeletal program is strong nationally,
the Penn biomedical research community is large and diverse. As such, the Center serves as an essential
mechanism to highlight our successes and the importance of musculoskeletal research across campus, as well
as to institutional leadership. Having a strong voice for musculoskeletal researchers for our ...

## Key facts

- **NIH application ID:** 10868633
- **Project number:** 5P30AR069619-09
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** LOUIS J SOSLOWSKY
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $895,284
- **Award type:** 5
- **Project period:** 2016-07-01 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10868633

## Citation

> US National Institutes of Health, RePORTER application 10868633, Overall: Resource-based Center for Musculoskeletal Disorders Research (Overall Application) (5P30AR069619-09). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10868633. Licensed CC0.

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