RESEARCH AND METHODS CORE ABSTRACT The Research and Methods Core (RMC) will serve as the hub in the University of Alabama at Birmingham (UAB)'s Center for Cancer Control in Persistent Poverty Areas (C3P2) that (1) provides methodological expertise on study design, analytic approaches, and statistical modelling to research projects, pilot projects, and other Center-generated research; (2) promotes the use of common data elements across projects and provide support on data measures, tools, integration, interoperability, and visualization; (3) provides expertise on the use of implementation strategies and dissemination of research findings to multiple stakeholder groups (e.g., investigators, community partners). The RMC will also play a critical role in supporting the research projects, pilot projects under the Development Core, and early-career scientists under the Career Enhancement Core. Additionally, in collaboration with Administrative Core, the RMC will participate in connecting the C3P2 to the Persistent Poverty Initiative Network (PPIN) and evaluating its research productivity and impact.