# The Exposome in Rheumatoid Arthritis and Systemic Lupus Erythematosus:  EXACT Network Planning

> **NIH NIH R21** · UNIVERSITY OF COLORADO DENVER · 2023 · $449,000

## Abstract

PROJECT SUMMARY
This is an exploratory developmental grant aimed at the design, development, and implementation of a future
national, interdisciplinary, collaborative, team science research network that will advance the study of the
exposome in autoimmune diseases (Exposome in Autoimmune Diseases Collaborating Teams, EXACT). We
propose to plan a study of the exposome during the pre-clinical period of rheumatoid arthritis (RA) and
systemic lupus erythematosus (SLE). We assert that it is important to measure the exposome prior to the
development of disease to ensure that what we are measuring precedes the disease and is not a consequence
of the disease (which might happen if the exposome were measured in diseased individuals). This will allow us
to draw inference about the temporality and potential causality of exposures on the risk of RA and SLE. This
can be accomplished using prospective cohorts of at-risk individuals that are followed for the development of
clinical disease (ie classifiable RA and SLE) with which we have a long history of working. Investigators at the
University of Colorado Anschutz Medical Campus (Norris, Holers and Abraham) will work with investigators at
the Oklahoma Medical Research Foundation (James and Munroe) to conduct a landscape analysis of relevant
existing 1) resources, populations, databases, registries, repositories and consortia, 2) data on relevant
exposures, 3) exposome laboratories, and 4) exposome analytic techniques. This will provide a background
that we will use to plan activities for a new project to study the exposome in RA and SLE. As part of the
planning process, we will hold a summit of exposome experts and investigators with cohorts/populations of
individuals at-risk for RA and SLE, to develop and expand existing research collaborations to conduct a
prospective study in the exposome of these diseases. We will use our existing novel cohorts of at-risk
individuals who have been followed to the development of classifiable RA and SLE to explore feasibility of
harmonization of questionnaire and biomarker data and conduct secondary data analysis to support the
hypothesis and research strategy of the future EXACT Network. We will engage stakeholders such as scientific
or professional associations and patients and patient-advocates in the areas of RA and SLE for better
translation to inform the EXACT Network research agenda. The overall goal of this proposal is to plan research
strategies and develop partnerships, infrastructure, and capabilities needed to address the major goals of a
future collaborative EXACT network and to develop a research framework and strategies to support
coordination among studies, collaborative research projects, and sites. Specific Aim 1. To conduct a
multipronged approach to determine the needs and currently available resources to prospectively and
effectively measure the exposome in RA and SLE (via a landscape analysis). Specific Aim 2. To design a
prospective study to examine th...

## Key facts

- **NIH application ID:** 10869439
- **Project number:** 1R21AR084036-01
- **Recipient organization:** UNIVERSITY OF COLORADO DENVER
- **Principal Investigator:** JILL M NORRIS
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $449,000
- **Award type:** 1
- **Project period:** 2023-09-19 → 2026-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10869439

## Citation

> US National Institutes of Health, RePORTER application 10869439, The Exposome in Rheumatoid Arthritis and Systemic Lupus Erythematosus:  EXACT Network Planning (1R21AR084036-01). Retrieved via AI Analytics 2026-07-25 from https://api.ai-analytics.org/grant/nih/10869439. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*