PROJECT SUMMARY The Administrative Core (Core A), led by Dr. Hefty (PI) and working with the co-Investigator, Program Manager, Core Directors and Leaders, Project Investigators, Mentors, and KU professional staff will; 1) provide scientific leadership, administration, support for CBID Research and Pilot Projects, Research Cores, and all associated scientists to best enable their successes and sustainability, 2) establish milestones and implement formative and summative evaluation strategies to actively mentor program scientists, 3) ensure the optimal selection and replacement of Research or Pilot Projects and Scientists, and 4) provide development and outreach opportunities for CBID Center scientists. Formal and informal reviews of the center and center projects will be accomplished in coordination with a distinguished External Advisory Committee, who will also work with the PI and co-I, to monitor progress metrics and provide guidance as to overall scientific direction for the cores. All fiduciary matters related to the CBID and program reporting will be managed by Core A, working with grant management professionals in KU Shared Services Center, Office of Research, and the Higuchi Biosciences Center.