The purpose of our program is to provide a broad-based, multidisciplinary training experience for pre-doctoral fellows, postdoctoral fellows, and summer medical students in the area of integrative cardiovascular pathophysiology (ICVP). ICVP faculty members are affiliated with various basic science and clinical departments, with research laboratories primarily located within the Department of Cardiovascular Sciences, housed on two adjacent floors of a new medical research building. ICVP investigators and mentors have shared interests in the fundamental properties of the cardiovascular system and the pathological changes that contribute to cardiovascular dysfunction in diseases such as ischemic heart disease, hypertensive heart disease, atherosclerosis, ischemic vascular disease, metabolic syndrome, and diabetic cardiovascular disease. Graduate students and postdoctoral fellows will receive didactic training in human physiology and pathophysiology, along with advanced instruction in cellular and molecular biology and the appropriate use of animal models of human cardiovascular disease. Research projects for graduate students and fellows will include both basic and translational components. Trainees will be encouraged to investigate problems that extend beyond single-molecule studies, addressing complex questions within the broader context of cardiovascular disease models. Portions of these projects will be conducted in the laboratories of multiple investigators, providing trainees with exposure to diverse scientific approaches. All trainees will participate in activities designed to strengthen their grant writing, manuscript preparation, and oral communication skills. Group mentoring by both junior and senior faculty will ensure that trainees are well prepared to become leading investigators capable of rapidly translating new scientific knowledge into novel therapies or therapeutic targets. Recruitment strategies will focus on attracting highly qualified candidates with the potential to contribute meaningfully to the advancement of cardiovascular science. The overarching goal is to train the next generation of biomedical scientists who are equipped to develop innovative therapies for cardiovascular disease.