Project Summary/Abstract Cerebrovascular disease is the 2nd leading cause of mortality in the world showing 17.2% in 2019. Approximately 795,000 strokes occur in the US every year, which are projected to expand to 1.25 million cases by 2025. Current approaches to treat intracranial blood vessels include medical, surgical, and endovascular methods. Among them, endovascular technologies with clot retriever thrombectomy devices, flow diverters, and embolization coils, etc. have been widely used to treat cerebrovascular disease since they are less invasive, more effective, and less risky. The typical endovascular sequence uses a micro guidewire to access target lesions, followed by tracking a catheter over the wire. However, even skilled interventionalists often encounter difficulties in translating proximal catheter/guidewire movements into anticipated movements at its distal end due mainly to unpredictable jerky and whipping motions of the pre-bent guidewire tip, particularly while navigating narrow and winding pathways. These issues cause prolonged operational procedures that increase the risk to expose interventionalists and patients to a high level of harmful X-ray radiation. To mitigate these issues in the current endovascular procedures, automated steering methods of guidewires have been introduced. As of today, however, a clinically practical solution for an ultra-low profile, simple, remotely controlled, automated steerable guidewire for neurointerventional procedures, which does not need to alter the materials or increase the overall dimensions in commercial endovascular products, is lacking. In this project, we will develop an innovative 𝜇Robot-guided system that allows for easy and rapid delivery of guidewires in challenging tortuous and complex neurovascular anatomy. The proposed 𝜇Robot is based on acoustic streaming that generates sufficient forces to steer guidewires three dimensionally and can be easily integrated to the distal tip of existing commercial guidewires. Steering the proposed 𝜇Robot guidewires can be achieved by simply switching the frequency and amplitude of acoustic waves from a static, compact, remote acoustic source (similar to the clinically well-proven ultrasound imaging probe), not requiring any bulky actuator or robotic arm. Thus, the overall system is ultra-low profile, cost-effective, and safe to the human body, being expected to allow for full robotic/telerobotic neurovascular interventions substantially reducing the total procedure time and thus minimizing the exposure to harmful X-ray radiation. To materialize the proposed innovated concept, task plans are established (1) to determine design parameters in 𝜇Robot guidewires using a commercial CFD (computational fluid dynamics) package, (2) to fabricate 𝜇Robot prototypes utilizing a 2-photon polymerization-based 3-D printer, (3) to integrate fabricated 𝜇Robot prototypes to commercial guidewires and characterize their steering motions, and (4) to assess the maneu...