# Unraveling how neuropathic pain synaptic transcriptome is signaled by G-quadruplex folds

> **NIH NIH R21** · SAINT LOUIS UNIVERSITY · 2024 · $189,375

## Abstract

PROJECT SUMMARY
 Neuropathic pain is a pervasive and debilitating condition associated with modifications in synaptic
plasticity and altered gene expression within the spinal cord. However, the specific molecular mechanisms
underlying these synaptic changes remain poorly understood. This proposed project aims to unravel the synaptic
transcriptome modifications occurring during neuropathic pain and investigate the involvement of G-
quadruplexes in translocation of transcripts at the synapse. The outcomes of this study will provide a
comprehensive map of the synaptic transcriptomic changes in neuropathic pain and elucidate some of the factors
contributing to this alteration. Furthermore, it will pave the way for the development of innovative therapeutic
strategies targeting the G-quadruplexes, ultimately offering new avenues for the management of neuropathic
pain.

## Key facts

- **NIH application ID:** 10870719
- **Project number:** 1R21NS137054-01
- **Recipient organization:** SAINT LOUIS UNIVERSITY
- **Principal Investigator:** Liberty Francois Ep Moutal
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $189,375
- **Award type:** 1
- **Project period:** 2024-03-15 → 2026-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10870719

## Citation

> US National Institutes of Health, RePORTER application 10870719, Unraveling how neuropathic pain synaptic transcriptome is signaled by G-quadruplex folds (1R21NS137054-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10870719. Licensed CC0.

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