Project Summary The exposome, defined as the measure of all exposures for an individual and how those exposures relate to an individual's health, plays a key role in many immune-mediated inflammatory skin diseases. Measuring the exposome over time and understanding its effect on human health using sophisticated readouts such as - omics assays is a key priority for future clinical and translational studies. However, one of the major barriers to conducting such longitudinal exposome studies is their frequent reliance on in-person clinical research visits. In-person research visits, often requiring time-consuming travel to an academic medical center and absence from work, can significantly limit the geographic, racial, and socioeconomic representation of research participants. These in-person visits also typically occur every few months, limiting the temporal resolution of exposome data that can be measured. This proposal focuses on the implementation of innovative strategies for remote, home-based exposome monitoring and -omics measurements. Successful completion of this work will provide valuable resources for a future collaborative network studying the exposome.