Project Summary/Abstract This application seeks funding for 10 trainees within the ChEM-H Chemistry-Biology Interface (CBI) predoctoral training program at Stanford University, aligned with the mission of the Stanford ChEM-H institute. Stanford ChEM-H was formed with the mission of bringing chemists, biologists, engineers and clinicians together to pursue a molecular level understanding of the principles underlying human health and to devise innovative disease interventions. The program’s primary mission is to cultivate interactions, thinking, and communication across the chemistry biology interface to enable innovations in the study and advancement of human health. The CBI Training Program will provide PhD students with a diverse community of peers and mentors from the Schools of Humanities and Sciences, Engineering, and Medicine. Graduate students in the program will be recruited from six PhD granting programs: Chemistry, Chemical Engineering, Chemical & Systems Biology, Biochemistry, Biology and Bioengineering. Appointed trainees are supported by the CBI Training Program for 2 years, usually the second- and third-year of graduate study. Mentors are affiliated with diverse departments and programs, including practicing physician scientists. Key components of the program are inclusion of students during the first year of graduate study, first-year laboratory rotations, coursework in chemical biology, instruction in the responsible conduct of research and enhancing reproducibility, student and faculty seminars, and career development activities. Professional development activities include a career panel, conference presentations, communication training for outreach, and an annual retreat. Students will also receive instruction on developing strategies to translate molecular findings to humans. The Training Program aims to increase trainee diversity within Stanford ChEM-H by maintaining 40% URM of trainee cohorts, building an inclusive community through mentor training, and retaining graduates in PhD programs and within the biomedical research workforce. Anticipated trainee outcomes are peer-reviewed publications at the chemistry biology interface, conference presentations, receipt of external funding, and retention within the biomedical research workforce in a variety of academic and non-academic positions. Students trained in this program will be exposed to a wide range of scientific concepts and techniques, meet diverse experts across the physical, life and medical sciences, and be uniquely situated to tackle challenges in human health from a molecular level perspective.