This study aims to increase equitable access to the Undiagnosed Diseases Network (UDN) in South Florida, particularly for underserved and minority populations. A retrospective review of 2093 UDN participants revealed an underrepresentation of Hispanic/Latino and black individuals compared to the U.S. Census data. Recognizing the need to improve the inclusion of minority populations, the UDN Miami Clinical Site is committed to enhancing recruitment, evaluation, and follow-up of individuals from these communities. Specific aims include actively recruiting underrepresented populations from the Caribbean and South/Central America, enrolling at least 10 additional participants from underserved and minority groups, and conducting comprehensive phenotypic characterizations to improve diagnostic efforts. The study will utilize state-of-the-art medical facilities, conduct in-person evaluations, and utilize a biorepository and CLIA laboratory for genomic analysis. The project aims to address disparities in access and diagnostic outcomes, leading to a more diverse and inclusive UDN cohort and improved outcomes for all participants.