PROJECT SUMMARY / ABSTRACT The mission of the Clinical Research Imaging Core (CRIC) is to advance cancer research at the University of Wisconsin Carbone Cancer Center (UWCCC) by supporting the accurate and efficient use of image- based outcome measures in oncology clinical research. CRIC does this by partnering with the Department of Radiology’s 1) Medical Imaging Research Support (MIRS), the imaging research administrative and support arm of Radiology, 2) Radius Core Lab, the dedicated image analysis lab within MIRS, and 3) Radiopharmaceutical Production Facility (RPF). CRIC provides UWCCC members and Disease-Oriented Teams (DOTs) with a dedicated clinical research imaging support hub that is integrated with their clinical studies and aligned with their research interests and initiatives to successfully incorporate conventional and novel clinical oncology imaging. Aim 1: CRIC provides UWCCC clinical trial protocol imaging and radiopharmaceutical feasibility review to identify and navigate any obstacles to study activation and clinical trial workflow implementation. This includes addressing feasibility, technical, and regulatory considerations for standard-of-care and investigational imaging techniques needed for study activation, and determining appropriate tumor response assessment imaging methodologies. Aim 2: CRIC partners with MIRS for coordination of proper UWCCC cancer-specific clinical research integration and imaging resource use, and with RPF for PET imaging needs. CRIC serves as the liaison for communication and integration of UWCCC clinical trial research needs with MIRS imaging workflows, infrastructure, and personnel. CRIC ensures UWCCC members and DOTs access to research scanner use and imaging support, including enabling application of novel investigational imaging methods. CRIC coordinates with the RPF for inclusion of clinical or investigational PET imaging agents in UWCCC clinical trials. Aim 3: CRIC partners with MIRS Radius Core Lab to provide imaging tumor response assessment services for accurate and efficient image-based outcome measures in UWCCC clinical trials. This partnership between CRIC and the Radius Core Lab brings expert image analysis and review by experienced radiology faculty to UWCCC clinical trials with detailed standardized reports, using standard CT anatomic tumor response assessments and those that are PET/CT based. Aim 4: CRIC will facilitate the development and expansion of emerging UWCCC theranostic clinical trials. Theranostics involves the use of radiopharmaceuticals for cancer diagnostics and therapy. CRIC will play a vital role in expanding theranostics trials at UWCCC through a developing Theranostic DOT and dosimetry service. Impact: CRIC in partnership with Radiology’s MIRS, MIRS Radius Core Lab, and RPF ensures efficient and accurate application of standard-of-care and innovative novel imaging methods, along with imaging expertise, to advance imaging-based metrics and support high-impact clinica...