Data Science Core Summary The Data Science Core for Biomedical Research (DSC), based at the University of Louisville Health Science Campus and the University of Kentucky, consists of several components designed to strengthen the research capacity of researchers and build upon data science training for faculty, staff, and students at primary undergraduate institutions (PUIs) within the larger KY INBRE network. Components of the DSC include the Bioinformatics Training and Education Center (BTEC), Genomics Training and Education Center (GTEC), Image Training and Education Center (ITEC), and the Predictive Analytics and Data Science (PADS) Hub that work together with the University of Louisville Bioinformatics Core (BC) and Sequencing Technology Center (STC). In order to fulfill the mission of the DSC within the KY INBRE network, seven specific aims have been established that will (1) support the generation and analysis of genomic datasets from Illumina, Pacific Biosciences, and Oxford Nanopore sequencing technologies; (2) provide hands-on training in imaging, genomics, and bioinformatic technologies; (3) provide expertise on experimental design and usage of appropriate statistical methodologies; (4) aid in the integration of publicly available data from resources such as dbGAP, GTEx, Genome Data Commons, The Cancer Genome Atlas, and ENCODE; (5) provide workshops for undergraduates, graduates, staff, and faculty; (6) support data science initiatives at PUIs; and (7) provide PUI access to scientific cores in IDeA states across the southeast region.