# Clinical and Translational Research Support Core  for Institution # 269291

> **NIH NIH P30** · TEMPLE UNIV OF THE COMMONWEALTH · 2024 · $405,723

## Abstract

SUMMARY
The current human immunodeficiency virus type 1 (HIV-1) pandemic is one where people living with HIV (PWH)
have had well-suppressed infection with therapy for prolonged periods of time. This has guided research towards
focusing on (i) comorbidities (aging, cardiovascular, cancer, metabolic, and immune activation), (ii) side effects
of antiretroviral therapy (ART), (iii) neurocognitive and behavioral disorders (occurs approximately 40% of the
time), (iv) social and structural determinants of NeuroHIV disparities, and (v) new therapeutics and cure
strategies. All of these areas rely on access to PWH and associated samples from PWH. Given these high-
priority areas of research, the Clinical and Translational Research Support Core (CTRSC), led by Dr. Wigdahl,
will have as its main SERVICE OBJECTIVE to enroll participants (White, Black, Hispanic and corresponding
uninfected participant cohorts) to continue the development of a rich and well-managed clinical population that
can provide data, advice, technical expertise, and reagents to address many of these questions. One of the main
research themes of this center focuses on latency, reservoirs, and cure strategies including reservoirs like the
central nervous system (CNS). As such, there is a pressing need to understand the genetics of the viral reservoir
and the genetic nature of the HIV-1 quasispecies in individuals well-suppressed by ART. Immunophenotyping
will also be performed to understand the immune response in PWH experiencing the aging process as well as
other comorbid conditions including substance abuse. In addition, having longitudinal samples from
neuropsychologically well-characterized PWH will facilitate longitudinal investigations involving biomarkers and
immune factors underlying neuroHIV. The CTRSC will accomplish these goals by (1) refinement and utilization
of the clinical cohort to examine parameters of HIV-1 disease and a number of comorbid factors (Szep/Pirrone),
(2) utilizing comprehensive neuropsychological evaluation to characterize the nature, progression, and
correlates of neurocognitive impairment in HIV-1 (Schultheis/Devlin), and (3) characterization of virological and
immunological parameters (Nonnemacher/ Haddad). The CTRSC will interface with the Central Administrative
and Management Core (CAMC) and will work closely in Aims 1 and 2 with the NeuroHIV and Community
Partnership and Disparities Core (NHCPDC). It will use the Viral Gene Editing and Bioinformatics Core (VGEBC)
for experimental design and informatic support of next-generation sequencing services (Aims 1 and 3) and the
Cell Biology and Functional Analyses Core (CBFAC) to help develop cell lines and isolate and develop primary
cell populations (Aim 3). Finally, the CTRSC will interact with early-career and established investigators from
within and outside the HIV community to develop new research questions and grants using the Developmental
and Research Mentorship Core (DRMC) and by providing scientifi...

## Key facts

- **NIH application ID:** 10873682
- **Project number:** 5P30MH092177-13
- **Recipient organization:** TEMPLE UNIV OF THE COMMONWEALTH
- **Principal Investigator:** Brian Wigdahl
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $405,723
- **Award type:** 5
- **Project period:** 2011-08-05 → 2027-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10873682

## Citation

> US National Institutes of Health, RePORTER application 10873682, Clinical and Translational Research Support Core  for Institution # 269291 (5P30MH092177-13). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10873682. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*