# Circadian Clock and Dietary Restriction

> **NIH NIH R01** · CLEVELAND STATE UNIVERSITY · 2024 · $483,243

## Abstract

Diet is an important factor influencing health and disease. Calorie restriction (CR) improves metabolism,
delays aging, and reduces the incidence of many age-associated diseases such as cancer, diabetes, and
cardiometabolic. mTOR signaling pathway plays a central role in the control of aging and CR mechanisms. We
will expand the current model on the regulation of mTOR signaling by diet in vivo, by exploring crosstalk
between diet and circadian rhythms in metabolic signaling and gene expression. We will test the hypothesis
that CR reprograms the expression of mTOR regulatory network through circadian clock-dependent
mechanisms. The reprogramming changes the balance in the mTOR network and impacts the response of
mTOR signaling to growth factors and nutrients challenges. Reprogramming of circadian rhythms in mTOR
signaling is important for metabolic adaptation to CR. In vivo and ex vivo approaches and wild-type and
circadian clock mutant mice will be used to compare the impact of CR with the impact of AL and fasting on
mTOR signaling. The study will help to dissect contributions of fasting and reduced calorie intake to CR
improved metabolism and longevity.

## Key facts

- **NIH application ID:** 10873771
- **Project number:** 5R01AG039547-13
- **Recipient organization:** CLEVELAND STATE UNIVERSITY
- **Principal Investigator:** Roman V Kondratov
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $483,243
- **Award type:** 5
- **Project period:** 2011-09-15 → 2027-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10873771

## Citation

> US National Institutes of Health, RePORTER application 10873771, Circadian Clock and Dietary Restriction (5R01AG039547-13). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10873771. Licensed CC0.

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