ABSTRACT – ADMINISTRATIVE CORE (Lead: Sallie Permar, Weill Cornell Medicine) The success of this renewal Program Project Grant and its scientific goals to assess both CMV immunity at the maternal-fetal interface and vaccine candidates in a preclinical NHP cCMV model will require a highly efficient and responsive Administrative Core (Admin Core). The Admin Core supports and manages the scientific Projects and Cores, along with the guidance of a Scientific Advisory Board (SAB) and NIH Program staff, ensuring steady progress toward meeting scientific milestones. The Administrative Core is essential for the Program because it will provide programmatic management, centralized data management, and coordination of financial and regulatory oversight, reducing the administrative burden of the individual Program components while guaranteeing efficiency and synergy across all Projects and Cores. Specifically, in Aim 1, the Admin Core will provide overall Program coordination, communications, and supporting resources to ensure close collaboration and scientific progress. Aim 2 will centralize data management to ensure scientific integrity and data sharing. Aim 3 will provide timely financial accounting and regulatory oversight to ensure compliance with institutional and federal research guidelines. By successfully completing its Aims, this Administrative Core will continue to ensure a unified research effort and support for the Program's overall goal to develop additional vaccine strategies, including targeting viral immune evasion proteins and eliciting local immunity at the maternal-fetal interface, that will be critical for effective vaccination against congenital CMV.