OTHER PROJECT INFORMATION – Summary/Abstract Administrative Core The Center mechanism for supporting scientific research offers important benefits beyond those available from a set of independent studies. The realization of these benefits, however, requires deliberate attention to coordination, collaboration, and integration in all aspects of the research process. The Administrative Core supports all domains of Center leadership, administrative support, trial metrics, and networking. The leadership role includes all aspects of programmatic and intellectual leadership. A key feature of this role is the integration of recommendations from the Center’s external advisory committee and review panels. The administrative support role involves clinical trial monitoring and all Center operational management. Key tasks include budget and personnel management, trial results reporting and dissemination, data and safety coordination, travel coordination, and meeting organization. The trial metrics role involves the development and utilization of metrics to evaluate clinical trial success. Metrics will be used to track trials’ output (e.g., publications, data resources), progression through the NIH Stage Model and representation across stages; gauge the diversity of our investigator community; and measure the number and type of collaborations. A key function is the ex-post examination of each trial’s ex-post statistical power and lessons learned for future work. Finally, the networking role will involve communications with Center and NBER affiliates, outreach to prospective trial investigators, and dissemination of trial results.