PROJECT ABSTRACT The goal of this Northwell Roybal Center for Personalized Trials: Physical Activity Promotion for Persons Giving Care or Living with AD/ADRD is to generate behavioral intervention development research for enhancing physical activity (Roybal Theme: Spur the Initiation and Maintenance of Physical Activity Regimens that are Personalized to Caregivers or Persons with AD/ADRD). The Northwell Roybal Center is comprised of two components: the Administrative Core and the Behavioral Intervention Development Core. Our Administrative Core will develop and provide the strategic vision, leadership, and the full range of NIH Stage Model expertise needed for the success of this Roybal Center; monitor Center clinical trials progress and provide immediate feedback; develop, identify, and use common metrics for Center productivity evaluation purposes. Finally, the core will facilitate collaboration with other Roybal Centers, the Coordinating Center, the National Institute on Aging, and scientists across the nation interested in advancing the initiation and maintenance of physical activity regimens personalized to care providers or those living with AD/ADRD. Our Behavioral Intervention Development (BID) Core will proactively determine a national pool of potential eligible scientists for later national competitions, review and select meritorious clinical trials for funding, and ensure compliance of all clinical trials with all regulatory agencies. The BID will then support investigators identified via this national competition to implement identified innovative clinical trials that align with the themes of the Northwell Roybal Center in Years 3 through 5 of the proposed project. The BID Core will also support the conduct of two Stage II fully-powered clinical trials in Years 1 and 2 that aim to foster habitual physical among caregivers for persons with AD/ADRD. Trial #1 will work to develop habitual daily walking among caregivers. In contrast, Trial #2 will develop habitual hourly walking to reduce the amount of time caregivers spend sedentary. Both trials will measure the key mechanism of behavior (MoBC) of cognitive automaticity. The overall mission of the Northwell Roybal Center for Personalized Trials is to establish an infrastructure organized per the NIH Stage Model with scientific expertise and resources to conduct Stages 0-V trials of the translational behavioral intervention development pipeline, as well as examining key MoBCs of behavior change, and so serve as a national resource for the behavioral and social intervention research community in initiating and maintaining personalized physical activity regimen for caregivers or persons living with AD/ADRD.