PROJECT ABSTRACT Core B – Behavioral Intervention Development Core The goal of the Behavioral Intervention Development Core of the Northwell Roybal Center for Personalized Trials: Physical Activity Promotion for Persons Giving Care or Living with AD/ADRD is to obtain the needed behavioral intervention development information and adequately powered trial results that can be translated into scalable, implementable interventions through innovative mechanisms of behavioral change (MoBC), behavior change theories and techniques, and innovative, personalized N-of-1 methods, where the latter are found to be effective and useful. The Behavioral Intervention Development (BID) Core will proactively determine a national pool of potential eligible scientists for later national competitions, review and select meritorious clinical trials for funding; and ensure compliance of all clinical trials with all regulatory agencies. The BID core will then support investigators identified via this national competition to implement identified innovative clinical trials which align with the themes of the Northwell Roybal Center in Years 3 through 5 of the proposed project. The BID Core will also support the conduct of two Stage II fully-powered clinical trials in Years 1 and 2 which aim to foster habitual physical among caregivers for persons with AD/ADRD. Trial #1 will work to develop habitual daily walking among caregivers while Trial #2 will work to develop habitual hourly walking as a means of reducing the amount of time caregivers spend sedentary. Both trials will measure the key mechanism of behavior (MoBC) of cognitive automaticity. The overall mission of the Northwell Roybal Center for Personalized Trials is to establish an infrastructure organized per the NIH Stage Model with scientific expertise and resources to conduct Stages 0-V trials of the translational behavioral intervention development pipeline, as well as examining key MoBCs Stages 0-V trials of behavior change, and so serve as a national resource for the behavioral and social intervention research community in initiating and maintaining personalized physical activity regimen for caregivers or persons living with AD/ADRD.